Human ACPP Recombinant Protein (RPPB5780)
- SKU:
- RPPB5780
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15309
- Research Area:
- Enzymes
Description
| Product Name: | Human ACPP Recombinant Protein |
| Product Code: | RPPB5780 |
| Size: | 20µg |
| Species: | Human |
| Target: | ACPP |
| Synonyms: | PAP, ACP3, ACP-3, Acid phosphatase, prostate, 5'-nucleotidase,5'-NT, Ecto-5'-nucleotidase, Thiamine monophosphatase, TMPase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ACPP protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSHMKELKFVTLV FRHGDRSPID TFPTDPIKES SWPQGFGQLT QLGMEQHYEL GEYIRKRYRK FLNESYKHEQ VYIRSTDVDRTLMSAMTNLA ALVPPEGVSI WNPILLWQPI PVHTVPLSED QLLYLPFRNC PRFQELESET LKSEEFQKRLHPYKDFIATL GKLSGLHGQD LFGIWSKVYD PLYCESVHNF TLPSRATEDT MTKLRELSEL SLLSLYGIHKQKEKSRLQGG VLVNEILNHM KRATQIPSYK KLIMYSAHDT TVSGLQMALD VYNGLLPPYA SCHLTELYFEKGEYFVEMYY RNETQHEPYP LMLPGCSPSC PLERFAELVG PVIPQDWSTE CMTTNSHQGT EDSTD |
Acid phosphatase, prostate (ACPP) is a non-specific tyrosine phosphatase, which dephosphorylates a varied number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. ACPP has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
ACPP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 375 amino acids (33-386 a.a) and having a molecular mass of 43.2kDa.ACPP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACPP: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.2; Cofactor and Vitamin Metabolism - riboflavin; Phosphatase; EC 3.1.3.5; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3q22.1 Cellular Component: multivesicular body; extracellular space; Golgi cisterna; apical part of cell; lysosomal membrane; plasma membrane; integral to membrane; vesicle membrane; intracellular; nucleus; secretory granule; filopodium Molecular Function:5'-nucleotidase activity; choline binding; identical protein binding; acid phosphatase activity; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process |
| NCBI Summary: | This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P15309 |
| NCBI GenInfo Identifier: | 130730 |
| NCBI Gene ID: | 55 |
| NCBI Accession: | P15309.3 |
| UniProt Related Accession: | P15309 |
| Molecular Weight: | |
| NCBI Full Name: | Prostatic acid phosphatase |
| NCBI Synonym Full Names: | acid phosphatase, prostate |
| NCBI Official Symbol: | ACPP�� |
| NCBI Official Synonym Symbols: | ACP3; 5'-NT; ACP-3�� |
| NCBI Protein Information: | prostatic acid phosphatase |
| UniProt Protein Name: | Prostatic acid phosphatase |
| UniProt Synonym Protein Names: | 5'-nucleotidase (EC:3.1.3.5); 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase |
| UniProt Gene Name: | ACPP�� |
| UniProt Entry Name: | PPAP_HUMAN |
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