Human ACP6 Recombinant Protein (RPPB1340)
- SKU:
- RPPB1340
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NPH0
- Research Area:
- Enzymes
Description
| Product Name: | Human ACP6 Recombinant Protein |
| Product Code: | RPPB1340 |
| Size: | 20µg |
| Species: | Human |
| Target: | ACP6 |
| Synonyms: | AcidPhosphatase 6, Lysophosphatidic, Acid Phosphatase-Like Protein 1, PACPL1,ACPL1, LPAP, Lysophosphatidic Acid Phosphatase Type 6, Lysophosphatidic AcidPhosphatase 6, Acid Phosphatase Like 1, EC 3.1.3.2, Lysophosphatidic acidphosphatase type 6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | ACP6 protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSELQEADG QCPVDRSLLK LKMVQVVFRH GARSPLKPLP LEEQVEWNPQLLEVPPQTQF DYTVTNLAGG PKPYSPYDSQ YHETTLKGGM FAGQLTKVGM QQMFALGERL RKNYVEDIPFLSPTFNPQEV FIRSTNIFRN LESTRCLLAG LFQCQKEGPIIIHTDEADSE VLYPNYQSCW SLRQRTRGRR QTASLQPGIS EDLKKVKDRMGIDSSDKVDF FILLDNVAAE QAHNLPSCPM LKRFARMIEQ RAVDTSLYIL PKEDRESLQM AVGPFLHILESNLLKAMDSA TAPDKIRKLY LYAAHDVTFI PLLMTLGIFD HKWPPFAVDL TMELYQHLESKEWFVQLYYH GKEQVPRGCPDGLCPLDMFL NAMSVYTLSP EKYHALCSQT QVMEVGNEE |
| Biological Activity: | Specific activity is > 70 units/mg, and is defined as the amount of enzyme which hydrolyze 1.0 nmoles of p-nitrophenyl phosphate (pNPP) per minute at PH�5.0 at 37C. |
Acid Phosphatase-6, also known as ACP6 is Hydrolyzes lysophosphatidicacid (LPA) which contains a medium length fatty acid chain to the correspondingmonoacylglycerol. ACP6 shows highest activity with lysophosphatidic acid whichcontains myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0),and lower activity with C18:0 as well as C6:0 lysophosphatidic acid.
ACP6 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 419 amino acids (33-428a.a) andhaving a molecular mass of 47.7kDa.ACP6 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACP6: Hydrolyzes lysophosphatidic acid to monoacylglycerol. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Mitochondrial; EC 3.1.3.2; Secreted; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; mitochondrion Biological Process: phospholipid metabolic process |
| NCBI Summary: | This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016] |
| UniProt Code: | Q9NPH0 |
| NCBI GenInfo Identifier: | 317373268 |
| NCBI Gene ID: | 51205 |
| NCBI Accession: | Q9NPH0.2 |
| UniProt Secondary Accession: | Q9NPH0,Q59G61, Q5T490, Q6IAQ3, Q7LG81, Q9UIG6, |
| UniProt Related Accession: | Q9NPH0 |
| Molecular Weight: | 30,790 Da |
| NCBI Full Name: | Lysophosphatidic acid phosphatase type 6 |
| NCBI Synonym Full Names: | acid phosphatase 6, lysophosphatidic |
| NCBI Official Symbol: | ACP6�� |
| NCBI Official Synonym Symbols: | LPAP; ACPL1; PACPL1�� |
| NCBI Protein Information: | lysophosphatidic acid phosphatase type 6 |
| UniProt Protein Name: | Lysophosphatidic acid phosphatase type 6 |
| UniProt Synonym Protein Names: | Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1 |
| Protein Family: | Lysophosphatidic acid phosphatase |
| UniProt Gene Name: | ACP6�� |
| UniProt Entry Name: | PPA6_HUMAN |
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