Nanodisc Human ACM3-Strep Protein (HDFP908)
- SKU:
- HDFP908
- Size:
- 10μg
- Target:
- ACM3
- Tag:
- C-Flag&Strep Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
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Description
| Product Name: | Nanodisc Human ACM3-Strep Protein |
| SKU: | HDFP908 |
| Size: | 10μg |
| Target: | ACM3 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | EGBRS, HM3, PBS |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human ACM3-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Calcium regulation in cardiac cells, GPCRDB Class A Rhodopsin-like, GPCRDB Other, Monoamine GPCRs, Regulation of Actin Cytoskeleton KEGG, Metabolic and Obesity. |
| Molecular Weight: | The human full length ACM3-Strep protein has a MW of 66.1 kDa |
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
| Uniprot ID: | P20309 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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