Human ACAA2 Recombinant Protein (RPPB5765)
- SKU:
- RPPB5765
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P42765
- Research Area:
- Enzymes
Description
| Product Name: | Human ACAA2 Recombinant Protein |
| Product Code: | RPPB5765 |
| Size: | 10µg |
| Species: | Human |
| Target: | ACAA2 |
| Synonyms: | DSAEC, 3-ketoacyl-CoA thiolase, mitochondrial, Acetyl-CoA acyltransferase, Beta-ketothiolase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The ACAA2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFGAYGGL LKDFTATDLS EFAAKAALSA GKVSPETVDS VIMGNVLQSS SDAIYLARHV GLRVGIPKET PALTINRLCG SGFQSIVNGC QEICVKEAEV VLCGGTESMS QAPYCVRNVR FGTKLGSDIK LEDSLWVSLT DQHVQLPMAM TAENLAVKHK ISREECDKYA LQSQQRWKAA NDAGYFNDEM APIEVKTKKG KQTMQVDEHA RPQTTLEQLQ KLPPVFKKDG TVTAGNASGV ADGAGAVIIA SEDAVKKHNF TPLARIVGYF VSGCDPSIMG IGPVPAISGA LKKAGLSLKD MDLVEVNEAF APQYLAVERS LDLDISKTNV NGGAIALGHP LGGSGSRITA HLVHELRRRG GKYAVGSACI GGGQGIAVII QSTA |
Acetyl-COA Acyltransferase 2, (ACAA2) is a member of the thiolase family. ACAA2 catalyzes the final step of the mitochondrial fatty acid beta-oxidation spiral. Not like most mitochondrial matrix proteins, ACAA2 contains a non-cleavable amino-terminal targeting signal.
ACAA2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 404 amino acids (17-397) and having a molecular mass of 42.6kDa.ACAA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACAA2: Abolishes BNIP3-mediated apoptosis and mitochondrial damage. Belongs to the thiolase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.1.16; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Transferase Chromosomal Location of Human Ortholog: 18q21.1 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:acetyl-CoA C-acyltransferase activity; protein binding; RNA binding Biological Process: fatty acid beta-oxidation |
| NCBI Summary: | The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42765 |
| NCBI GenInfo Identifier: | 167614485 |
| NCBI Gene ID: | 10449 |
| NCBI Accession: | NP_006102.2 |
| UniProt Secondary Accession: | P42765,Q9BUT6, |
| UniProt Related Accession: | P42765 |
| Molecular Weight: | |
| NCBI Full Name: | 3-ketoacyl-CoA thiolase, mitochondrial |
| NCBI Synonym Full Names: | acetyl-CoA acyltransferase 2 |
| NCBI Official Symbol: | ACAA2�� |
| NCBI Official Synonym Symbols: | DSAEC�� |
| NCBI Protein Information: | 3-ketoacyl-CoA thiolase, mitochondrial |
| UniProt Protein Name: | 3-ketoacyl-CoA thiolase, mitochondrial |
| UniProt Synonym Protein Names: | Acetyl-CoA acyltransferase; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1 |
| Protein Family: | 3-ketoacyl-CoA thiolase |
| UniProt Gene Name: | ACAA2�� |
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