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Human 5HT2A-Strep full length protein-synthetic nanodisc (HDFP895)

SKU:
HDFP895
Size:
10μg
Target:
5HT2A
Tag:
C-Flag&Strep Tag
Expression Host:
HEK293
Conjugate:
Unconjugated
€1,249
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Description

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Product Name:Nanodisc Human 5HT2A-Strep Protein
SKU:HDFP895
Size:10μg
Target:5HT2A
Tag:C-Flag&Strep Tag
Expression Host:HEK293
Conjugate:Unconjugated
Synonyms:5-HT2A, HTR2
Protein Families:GPCR, Transmembrane, Druggable Genome.
Protein Description:Human 5HT2A-Strep full length protein-synthetic nanodisc
Protein Pathways:GPCRDB Class A Rhodopsin-like, GPCRDB Other, Monoamine GPCRs, Metabolic and Obesity.
Molecular Weight:The human full length 5HT2A-Strep protein has a MW of 52.6 kDa

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot ID:P28223
Formulation & Reconstitution:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Usage:Research use only

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