The HTRA2 Rabbit Monoclonal Antibody (CAB3904) is a valuable tool for researchers studying the HTRA2 protein, which is involved in various cellular processes, including apoptosis and mitochondrial function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to HTRA2, researchers can detect and analyze the protein in different cell types, making it an essential tool for studies in molecular biology and cell signaling pathways.HTRA2, also known as high-temperature requirement protein A2, is a serine protease that plays a critical role in maintaining cellular homeostasis and responding to cellular stress.
Dysregulation of HTRA2 has been implicated in various diseases, including neurodegenerative disorders and cancer. Research into the function of HTRA2 is essential for understanding its role in disease pathology and identifying potential therapeutic targets for intervention. The HTRA2 Rabbit Monoclonal Antibody (CAB3904) is a valuable tool for researchers working in these areas of study.
Product Name:
HTRA2 Rabbit Monoclonal Antibody
SKU:
CAB3904
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HTRA2 (O43464).
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
27429
Clone Number:
ARC0864
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HTRA2 Rabbit mAb (CAB3904) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
