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HTRA2 Monoclonal Antibody [PAT4G8AT] (CPAB0197)

SKU:
CPAB0197
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT4G8AT
Applications:
WB
ELISA
€149
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Description

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HTRA2 Monoclonal Antibody [PAT4G8AT] (CPAB0197)

The HTRA2 Polyclonal Antibody (CPAB0197) is a vital tool for researchers studying the mitochondrial serine protease HTRA2, a protein with important roles in cell survival and apoptosis. This antibody has been raised in rabbits and is highly reactive with human samples, making it an ideal choice for Western blot applications. By binding to the HTRA2 protein, this antibody enables precise detection and analysis in a variety of cell types, allowing for in-depth study of its functions in cellular processes and diseases.HTRA2, also known as Omi, is a key player in mitochondrial quality control and regulation of cell death pathways.

Dysregulation of HTRA2 has been linked to various diseases such as neurodegenerative disorders, cancer, and metabolic syndromes. Understanding the molecular mechanisms and signaling pathways involving HTRA2 is essential for developing targeted therapies and interventions for these conditions.Overall, the HTRA2 Polyclonal Antibody (CPAB0197) provides researchers with a reliable tool to investigate the function and regulation of HTRA2, offering valuable insights into its potential as a therapeutic target in various diseases.

Product Name:HTRA2 Antibody
Product Sku:CPAB0197
Size:5μg
Host Species:Mouse
Immunogen:Anti-human HTRA2 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human HTRA2 protein 134-458 amino acids purified from Ecoli.
Clone:PAT4G8AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:HTRA2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:HtrA2 also called Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death.
Synonyms:Serine protease HTRA2 mitochondrial, EC 3.4.21.108, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine proteinase OMI, Serine protease 25, OMI, PARK13, PRSS25.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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