The HTR3E Polyclonal Antibody (PACO64083) is a valuable tool for researchers studying the 5-HT3E receptor, a member of the serotonin receptor family involved in neurotransmission and gastrointestinal function. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the HTR3E protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in neuroscience and gastrointestinal research.The HTR3E receptor is known for its role in modulating serotonin-mediated signaling pathways, particularly in the central and peripheral nervous systems.
Dysregulation of HTR3E function has been implicated in various neurological and gastrointestinal disorders, making it an attractive target for therapeutic intervention. Research into the mechanisms underlying HTR3E activity is essential for advancing our understanding of conditions such as irritable bowel syndrome, depression, and anxiety, paving the way for the development of novel treatment strategies.
Antibody Name:
HTR3E Antibody (PACO64083)
Antibody SKU:
PACO64083
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human 5-hydroxytryptamine receptor 3E protein (26-248AA)
Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate, Rat Heart tissue, Mouse Heart tissue. All lanes: HTR3E antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52, 50, 53, 51, 54 kDa. Observed band size: 50 kDa.
Background:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Synonyms:
5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E), HTR3E
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
