The HTR3D Polyclonal Antibody (PAC036858) is a valuable tool for researchers studying the 5-HT3D receptor, a member of the serotonin receptor family that plays a role in neurotransmission and gastrointestinal function. This rabbit-derived antibody is highly specific to human samples and is validated for use in various applications, including Western blotting. By binding to the HTR3D receptor protein, this antibody enables researchers to detect and analyze its expression in different cell types, making it an ideal choice for studies in neuroscience and gastrointestinal research.The HTR3D receptor is known for its involvement in modulating serotonin signaling, which can have a significant impact on mood, appetite, and gut motility.
Dysfunction of this receptor has been implicated in various neurological and gastrointestinal disorders, making it a promising target for therapeutic interventions. Understanding the function of the HTR3D receptor is crucial for developing treatments that target serotonin signaling pathways in conditions such as depression, irritable bowel syndrome, and nausea.Overall, the HTR3D Polyclonal Antibody offers researchers a reliable tool for investigating the role of the HTR3D receptor in health and disease, providing valuable insights into potential therapeutic strategies for a range of neurological and gastrointestinal conditions.
Western blot. All lanes: HTR3D antibody at 2µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 51, 31, 26, 46 kDa. Observed band size: 51 kDa.
Immunofluorescent analysis of Hela cells using PACO36858 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Synonyms:
5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D), HTR3D
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
