HTR1E Antibody (PACO27465)
- SKU:
- PACO27465
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HTR1E Antibody (PACO27465)
The HTR1E Monoclonal Antibody (PACO27465) is a valuable tool for researchers studying the serotonin receptor 1E (HTR1E), a G protein-coupled receptor involved in the regulation of serotonin signaling and neurotransmission. This antibody, generated from mouse hybridoma cells, shows high specificity for HTR1E in human samples and is suitable for use in various applications, including immunohistochemistry and flow cytometry.HTR1E is known for its role in modulating serotonin levels in the brain, affecting mood, anxiety, and other neurological processes. Dysregulation of HTR1E has been associated with psychiatric disorders such as depression and anxiety disorders, making it a key target for drug development and therapies targeting the serotonin system.
By utilizing the HTR1E Monoclonal Antibody, researchers can investigate the expression and localization of HTR1E in different tissues and cell types, providing insights into its function and potential involvement in neurological disorders. This antibody is a valuable tool for advancing our understanding of serotonin signaling and its impact on mental health.
| Antibody Name: | HTR1E Antibody (PACO27465) |
| Antibody SKU: | PACO27465 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human 5-hydroxytryptamine receptor 1E protein (203-291AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: HTR1E antibody at 3.3µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 42 kDa Observed band size: 42 kDa . |
 | Immunohistochemistry analysis of human lung cancer using PACO27465 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO27465 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. |
| Synonyms: | 5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E), HTR1E |
| UniProt Protein Function: | 5-HT(1E): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6q14-q15Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; protein binding; serotonin binding; serotonin receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cyclic nucleotide second messenger |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P28566 |
| NCBI GenInfo Identifier: | 112822 |
| NCBI Gene ID: | 3354 |
| NCBI Accession: | P28566.1 |
| UniProt Secondary Accession: | P28566,Q9P1Y1, E1P503 |
| UniProt Related Accession: | P28566 |
| Molecular Weight: | 41,682 Da |
| NCBI Full Name: | 5-hydroxytryptamine receptor 1E |
| NCBI Synonym Full Names: | 5-hydroxytryptamine receptor 1E |
| NCBI Official Symbol: | HTR1EÂ Â |
| NCBI Official Synonym Symbols: | 5-HT1EÂ Â |
| NCBI Protein Information: | 5-hydroxytryptamine receptor 1E |
| UniProt Protein Name: | 5-hydroxytryptamine receptor 1E |
| UniProt Synonym Protein Names: | S31; Serotonin receptor 1E |
| Protein Family: | 5-hydroxytryptamine receptor |
| UniProt Gene Name: | HTR1EÂ Â |
| UniProt Entry Name: | 5HT1E_HUMAN |
| Antibodies |
| HTR1E Antibody (PACO01534) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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HTR1E Antibody (PACO01534)
