The HTR1B Polyclonal Antibody (CAB18285) is a rabbit-derived antibody specifically designed for research targeting the HTR1B protein, a serotonin receptor that plays a crucial role in the regulation of mood and anxiety. This antibody is highly reactive with human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of HTR1B in various cell types.The HTR1B protein is a key player in the serotonergic system, a neurotransmitter system that has been implicated in a wide range of physiological and psychological processes. Dysregulation of the serotonergic system, including alterations in HTR1B function, has been associated with mood disorders such as depression and anxiety.
Research into the function and regulation of HTR1B is therefore essential for better understanding these disorders and developing more effective treatments.Studies using the HTR1B Polyclonal Antibody can shed light on the mechanisms by which this receptor modulates serotonin signaling and its impact on mood and anxiety-related behaviors. By elucidating the role of HTR1B in normal physiology and disease states, researchers can potentially identify new therapeutic targets for mental health conditions.
Product Name:
HTR1B Rabbit Polyclonal Antibody
SKU:
CAB18285
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-390 of human HTR1B (P28222).
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.
Purification Method:
Affinity purification
Gene ID:
3351
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HTR1B Rabbit pAb (CAB18285) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
