The HTR1A Polyclonal Antibody (CAB2801) is a valuable tool for researchers studying the HTR1A receptor, a key player in serotonin signaling and neurotransmission. This antibody, developed using rabbits as the host species, is highly specific and reliable for detecting HTR1A in human samples, making it suitable for a variety of research applications, including Western blotting. By targeting the HTR1A protein, this antibody enables precise detection and analysis in various cell types, providing insights into the role of serotonin receptors in neurological and psychiatric disorders.
The HTR1A receptor is involved in mood regulation, anxiety, and stress response, making it a promising target for investigating conditions such as depression, anxiety disorders, and schizophrenia. By understanding the function and regulation of the HTR1A receptor, researchers can develop novel therapeutic strategies for treating these debilitating conditions.
Product Name:
HTR1A Rabbit Polyclonal Antibody
SKU:
CAB2801
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 261-305 of human HTR1A (NP_000515.2).
Sequence:
RNWR LGVE SKAG GALC ANGA VRQG DDGA ALEV IEVH RVGN SKEH L
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
Purification Method:
Affinity purification
Gene ID:
3350
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HTR1A Rabbit pAb (CAB2801) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
