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HTN3 Antibody (PACO64275)

SKU:
PACO64275
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$431

Description

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HTN3 Antibody (PACO64275)

The HTN3 Polyclonal Antibody (PAC064275) is a powerful tool for research involving HTN3, a protein associated with neuronal function and synaptic plasticity. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in immunohistochemistry and immunofluorescence applications. By binding specifically to HTN3, researchers can detect and study the protein's expression and localization in various tissues and cell types, making it an essential reagent for neuroscience and neurobiology studies.

HTN3, also known as histatin-3, is a multifunctional protein with roles in antimicrobial defense, wound healing, and synaptic transmission. Research on HTN3 is crucial for understanding its involvement in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and epilepsy. The HTN3 Polyclonal Antibody provides a reliable tool for investigating the functions and regulatory mechanisms of HTN3, offering insights into potential therapeutic targets for neurological conditions.

Antibody Name:HTN3 Antibody (PACO64275)
Antibody SKU:PACO64275
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:500
Species Reactivity:Human
Immunogen:Peptide sequence from Human Histatin-3 protein (20-34AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Antigen Affinity purified & Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO64275 diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG labeled by HRP and visualized using 0.05% DAB.
Background:Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
Synonyms:Histatin-3 (Basic histidine-rich protein) (Hst) (Histidine-rich protein 3) (PB) [Cleaved into: Histatin-3, His3-(20-44)-peptide (His3 20/44) (His3-(1-25)-peptide) (His3 1/25) (Histatin-3 1/25) (Histatin-6), His3-(20-43)-peptide (His3 20/43) (His3-(1-24)-peptide) (His3 1/24) (Histatin-3 1/24) (Histatin-5), His3-(20-32)-peptide (His3 20/32) (His3-(1-13)-peptide) (His3 1/13) (Histatin-3 1/13), His3-(20-31)-peptide (His3 20/31) (His3-(1-12)-peptide) (His3 1/12) (Histatin-3 1/12), His3-(20-30)-peptide (His3 20/30) (His3-(1-11)-peptide) (His3 1/11) (Histatin-3 1/11), His3-(24-32)-peptide (His3 24/32) (His3-(5-13)-peptide) (His3 5/13) (Histatin-3 5/13), His3-(24-31)-peptide (His3 24/31) (His3-(5-12)-peptide) (His3 5/12) (Histatin-11) (Histatin-3 5/12), His3-(24-30)-peptide (His3 24/30) (His3-(5-11)-peptide) (His3 5/11) (Histatin-12) (Histatin-3 5/11), His3-(25-32)-peptide (His3 25/32) (His3-(6-13)-peptide) (His3 6/13) (Histatin-3 6/13), His3-(25-30)-peptide (His3 25/30) (His3-(6-11)-peptide) (His3 6/11) (Histatin-3 6/11), His3-(26-32)-peptide (His3 26/32) (His3-(7-13)-peptide) (His3 7/13) (Histatin-3 7/13), His3-(26-31)-peptide (His3 26/31) (His3-(7-12)-peptide) (His3 7/12) (Histatin-3 7/12), His3-(26-30)-peptide (His3 26/30) (His3-(7-11)-peptide) (His3 7/11) (Histatin-3 7/11), His3-(31-51)-peptide (His3 31/51) (His3-(12-32)-peptide) (His3 12/32) (Histatin-3 12/32) (Histatin-4), His3-(31-44)-peptide (His3 31/44) (His3-(12-25)-peptide) (His3 12/25) (Histatin-3 12/25) (Histatin-9), His3-(31-43)-peptide (His3 31/43) (His3-(12-24)-peptide) (His3 12/24) (Histatin-3 12/24) (Histatin-7), His3-(32-44)-peptide (His3 32/44) (His3-(13-25)-peptide) (His3 13/25) (Histatin-10) (Histatin-3 13/25), His3-(32-43)-peptide (His3 32-43) (His3-(13-24)-peptide) (His3 13/24) (Histatin-3 13/24) (Histatin-8), His3-(33-44)-peptide (His3 33/44) (His3-(14-25)-peptide) (His3 14/25) (Histatin-3 14/25), His3-(33-43)-peptide (His3 33/43) (His3-(14-24)-peptide) (His3 14/24) (Histatin-3 14/24), His3-(34-44)-peptide (His3 34/44) (His3-(15-25)-peptide) (His3 15/25) (Histatin-3 15/25), His3-(34-43)-peptide (His3 34/43) (His3-(15-24)-peptide) (His3 15/24) (Histatin-3 15/24), His3-(45-51)-peptide (His3 45/51) (His3-(26-32)-peptide) (His3 26/32) (Histatin-3 26/32), His3-(47-51)-peptide (His3 47/51) (His3-(28-32)-peptide) (His3 28/32) (Histatin-3 28/32), His3-(48-51)-peptide (His3 48/51) (His3-(29-32)-peptide) (His3 29/32) (Histatin-3 29/32)], HTN3, HIS2
UniProt Protein Function:HTN3: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. Belongs to the histatin/statherin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: extracellular region

Molecular Function:protein binding; metal ion binding

Biological Process: killing of cells of another organism; biomineral formation; defense response to bacterium; defense response to fungus

NCBI Summary:This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
UniProt Code:P15516
NCBI GenInfo Identifier:4557653
NCBI Gene ID:3347
NCBI Accession:NP_000191.1
UniProt Secondary Accession:P15516,Q16243, Q502Z1,
UniProt Related Accession:P15516
Molecular Weight:6,149 Da
NCBI Full Name:histatin-3
NCBI Synonym Full Names:histatin 3
NCBI Official Symbol:HTN3  
NCBI Official Synonym Symbols:HIS2; HTN2; HTN5  
NCBI Protein Information:histatin-3; PB; hst; histatin 5; histatin-4; histatin-5; histatin-6; histatin-7; histatin-8; histatin-9; histidine-rich protein 3; basic histidine-rich protein
UniProt Protein Name:Histatin-3
UniProt Synonym Protein Names:Basic histidine-rich protein; Hst; Histidine-rich protein 3; PBCleaved into the following 26 chains:Histatin-3; His3-(20-44)-peptide; His3 20/44Alternative name(s):His3-(1-25)-peptide; His3 1/25; Histatin-3 1/25; Histatin-6
UniProt Gene Name:HTN3  
UniProt Entry Name:HIS3_HUMAN
ELISA Kits
Human Histatin-3 ELISA Kit
Human Histatin-3 (HTN3) ELISA Kit
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