The Hsph1 Polyclonal Antibody (CAB6622) is a valuable tool for researchers studying Hsph1, a protein involved in cellular stress responses and protein quality control. This antibody, generated in rabbits, has been shown to react specifically with human samples and is suitable for use in Western blot applications. By targeting the Hsph1 protein, this antibody allows for the detection and analysis of Hsph1 in various cell types, making it an ideal choice for studies related to cellular stress, protein folding, and proteostasis.Hsph1, also known as heat shock protein family H (Hsp110) member 1, is a chaperone protein that assists in the folding and unfolding of other proteins under stress conditions.
Its role in maintaining protein homeostasis and cellular viability has implications for various diseases, including neurodegenerative disorders and cancer. By studying the function of Hsph1, researchers can gain insights into how cells respond to stress and develop strategies for targeting Hsph1 in therapeutic interventions.Overall, the Hsph1 Polyclonal Antibody (CAB6622) provides a valuable tool for investigating the role of Hsph1 in cellular physiology and disease pathogenesis, offering new avenues for research and potential therapeutic development.
Product Name:
HSP105/HSPH1 Rabbit Polyclonal Antibody
SKU:
CAB6622
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 659-858 of human HSP105/HSP105/HSPH1 (NP_006635.2).
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
Purification Method:
Affinity purification
Gene ID:
10808
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSP105/HSPH1 Rabbit pAb (CAB6622) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
