HSPB8/HSP22 Rabbit Polyclonal Antibody (CAB2514)
- SKU:
- CAB2514
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | HSPB8/HSP22 Rabbit Polyclonal Antibody |
SKU: | CAB2514 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human HSPB8/HSP22 (NP_055180.1). |
Sequence: | MADG QMPF SCHY PSRL RRDP FRDS PLSS RLLD DGFG MDPF PDDL TASW PDWA LPRL SSAW PGTL RSGM VPRG PTAT ARFG VPAE GRTP PPFP GEPW KVCV NVHS FKPE ELMV KTKD GYVE VSGK HEEK QQEG GIVS KNFT KKIQ LPAE VDPV TVFA SLSP EGLL IIEA PQVP PYST FGES SFNN ELPQ DSQE VTCT |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; HSPB8/HSP22 |
Positive Sample: | RD,Mouse liver,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 22kDa |
Observed MW: | 22kDa |
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Purification Method: | Affinity purification |
Gene ID: | 26353 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |