The HSPB8 Polyclonal Antibody (CAB2514) is a key tool for researchers studying HSPB8, a heat shock protein known to play a critical role in cellular stress response. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting HSPB8 in human samples, making it an essential tool for Western blot applications. By targeting the HSPB8 protein, researchers can investigate its function in various cellular processes, particularly in the context of neurodegenerative diseases, muscle disorders, and cancer.
HSPB8, a member of the small heat shock protein family, is involved in protecting cells from stress-induced damage and maintaining protein homeostasis. Dysregulation of HSPB8 has been linked to the development of several diseases, making it a promising target for therapeutic interventions. With the HSPB8 Polyclonal Antibody, researchers can gain valuable insights into the role of HSPB8 in disease pathogenesis and potentially uncover new treatment strategies.
Product Name:
HSPB8/HSP22 Rabbit Polyclonal Antibody
SKU:
CAB2514
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human HSPB8/HSP22 (NP_055180.1).
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Purification Method:
Affinity purification
Gene ID:
26353
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSPB8/HSP22 Rabbit pAb (CAB2514) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
