HSPB8/HSP22 Rabbit Monoclonal Antibody (CAB13518)
- SKU:
- CAB13518
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | HSPB8/HSP22 Rabbit Monoclonal Antibody |
SKU: | CAB13518 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HSPB8/HSP22 (Q9UJY1). |
Sequence: | MADG QMPF SCHY PSRL RRDP FRDS PLSS RLLD DGFG MDPF PDDL TASW PDWA LPRL SSAW PGTL RSGM VPRG PTAT ARFG VPAE GRTP PPFP GEPW KVCV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; CRYAC; HSPB8/HSP22 |
Positive Sample: | Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 22kDa |
Observed MW: | 24kDa |
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Purification Method: | Affinity purification |
Gene ID: | 26353 |
Clone Number: | ARC0715 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |