The HSPB1 Polyclonal Antibody (CAB0240) is a valuable tool for researchers studying the heat shock protein beta-1 (HSPB1), also known as HSP27. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to HSPB1, this antibody allows for the detection and analysis of this important protein in a variety of cell types.HSPB1 is a chaperone protein that plays a key role in cellular stress response, particularly in protecting cells from damage caused by heat, oxidative stress, and other harmful conditions. Dysregulation of HSPB1 has been implicated in a range of diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer.
By studying HSPB1 using this polyclonal antibody, researchers can gain valuable insights into the mechanisms of disease and potentially identify new therapeutic targets.In summary, the HSPB1 Polyclonal Antibody (CAB0240) is a reliable tool for researchers investigating the function and regulation of HSPB1 in various disease contexts. Its high specificity and sensitivity make it an ideal choice for studies in cell biology, molecular biology, and biomedicine.
Product Name:
HSP27/HSPB1 Rabbit Polyclonal Antibody
SKU:
CAB0240
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human HSP27/HSPB1 (NP_001531.1).
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Purification Method:
Affinity purification
Gene ID:
3315
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Hep G2 cells using HSP27/HSPB1 Rabbit pAb (CAB0240) at 1:1000 dilution incubated overnight at 4℃.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
