HSPA9 Antibody (PACO06566)
- SKU:
- PACO06566
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
HSPA9 Antibody (PACO06566)
The HSPA9 Polyclonal Antibody (PACO06566) is a valuable tool for researchers studying HSPA9, a heat shock protein involved in protein folding and stress response. Raised in rabbits, this antibody is highly specific for human samples and is validated for use in Western blot applications. By binding to the HSPA9 protein, this antibody enables detection and analysis in various cell types, making it ideal for studies in molecular biology and cell stress research.HSPA9, also known as mortalin, plays a crucial role in maintaining cellular homeostasis by protecting proteins from cellular stress and preventing protein aggregation.
Its involvement in protein folding and degradation makes HSPA9 a key player in cellular health and disease progression. Research into HSPA9 can provide insights into various diseases such as neurodegenerative disorders, cancer, and metabolic diseases, and may lead to the development of new therapeutic strategies targeting protein quality control mechanisms. Overall, the HSPA9 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of HSPA9 in cellular stress response pathways and its implications in disease development and progression.
| Antibody Name: | HSPA9 Antibody (PACO06566) |
| Antibody SKU: | PACO06566 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat, Monkey |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human HSP A9. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of NIH-3T3 RAT-MUSCLE cells using HSP A9 Polyclonal Antibody. |
 | Western Blot analysis of COS7 cells using HSP A9 Polyclonal Antibody. |
| Synonyms: | HSPA9; GRP75; HSPA9B; Stress-70 protein; mitochondrial; 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74 |
| UniProt Protein Function: | HSPA9B: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Belongs to the heat shock protein 70 family. |
| UniProt Protein Details: | Protein type:Nucleolus; Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: focal adhesion; mitochondrion; cytoplasm; nucleolus Molecular Function:protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding Biological Process: cellular protein metabolic process; protein folding; protein export from nucleus; protein targeting to mitochondrion; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010] |
| UniProt Code: | P38646 |
| NCBI GenInfo Identifier: | 21264428 |
| NCBI Gene ID: | 3313 |
| NCBI Accession: | P38646.2 |
| UniProt Secondary Accession: | P38646,P30036, P31932, Q1HB43, Q53H23, Q6GU03, Q9BWB7 Q9UC56, B2RCM1, |
| UniProt Related Accession: | P38646 |
| Molecular Weight: | 679 |
| NCBI Full Name: | Stress-70 protein, mitochondrial |
| NCBI Synonym Full Names: | heat shock 70kDa protein 9 (mortalin) |
| NCBI Official Symbol: | HSPA9Â Â |
| NCBI Official Synonym Symbols: | CSA; MOT; MOT2; CRP40; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; HEL-S-124m  |
| NCBI Protein Information: | stress-70 protein, mitochondrial; mortalin-2; p66-mortalin; mortalin, perinuclear; heat shock 70kD protein 9B; peptide-binding protein 74; 75 kDa glucose-regulated protein; catecholamine-regulated protein 40; epididymis secretory sperm binding protein Li 124m |
| UniProt Protein Name: | Stress-70 protein, mitochondrial |
| UniProt Synonym Protein Names: | 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74 |
| Protein Family: | Stress-70 protein |
| UniProt Gene Name: | HSPA9Â Â |
| UniProt Entry Name: | GRP75_HUMAN |
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