The HSPA5 Polyclonal Antibody (PAC045918) is a valuable tool for researchers studying HSPA5, also known as BiP or GRP78, a key protein involved in the endoplasmic reticulum stress response. This antibody is raised in rabbits and has high reactivity with human samples, making it suitable for use in Western blot applications.HSPA5 plays a crucial role in protein folding and assembly, as well as in regulating the unfolded protein response. Dysregulation of HSPA5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By using the HSPA5 Polyclonal Antibody, researchers can detect and analyze HSPA5 levels in different cell types, providing insights into the mechanisms underlying these diseases.With its ability to specifically bind to the HSPA5 protein, this antibody is an essential tool for studies in molecular biology, cell biology, and disease pathology. Gain a better understanding of the functions and regulations of HSPA5 with the HSPA5 Polyclonal Antibody, advancing research in the fields of cancer biology, neurobiology, and cardiovascular research.
Western Blot. Positive WB detected in: Rat liver tissue, Rat brain tissue, Mouse brain tissue. All lanes: Hspa5 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 73 kDa. Observed band size: 73 kDa..
Immunofluorescent analysis of HepG2 cells using PACO45918 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).
Synonyms:
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein), Hspa5, Grp78
UniProt Protein Function:
Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum (PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (PubMed:12411443).
