HSPA1L Monoclonal Antibody (MACO0016)
- SKU:
- MACO0016
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Mouse
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Description
Anti-HSPA1L Antibody (MACO0016)
The HSPA1L Monoclonal Antibody (MACO0016) is a valuable tool for researchers studying the heat shock protein HSPA1L, which is involved in cellular stress response and protein folding processes. This antibody, produced using hybridoma technology, specifically targets HSPA1L in human samples and is validated for use in immunofluorescence and immunohistochemistry applications.HSPA1L, a member of the HSP70 family, plays a crucial role in maintaining cellular homeostasis by assisting in the folding of proteins under stress conditions. Its expression is upregulated in response to various environmental stressors, making it a key player in the cellular stress response pathway. By targeting HSPA1L with this monoclonal antibody, researchers can visualize and analyze the expression and localization of this protein in different cell types, providing insights into its function in health and disease.
The HSPA1L Monoclonal Antibody is a valuable tool for studies in cell biology, molecular biology, and cancer research, where understanding the role of heat shock proteins like HSPA1L is critical. By investigating the expression and function of HSPA1L using this antibody, researchers can gain valuable insights into the mechanisms underlying cellular stress response and potentially identify new therapeutic targets for diseases associated with protein misfolding and stress.
Product Name: | Anti-HSPA1L Antibody |
Product Sku: | MACO0016 |
Size: | 50ug |
Host Species: | Mouse |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200 |
Species Reactivity: | Human,Mouse,Rat |
Immunogen: | Synthetic Peptide |
Form: | Liquid |
Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Purification Method: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Clonality: | Monoclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | |
Synonyms: | Heat shock 70 kDa protein 1-like/Heat shock 70 kDa protein 1A/1B |
Western blot analysis of 1) Hela, 2) Mouse Brain, diluted at 1:2000. | |
IF analysis of Hela with antibody (Left) and DAPI (Right) diluted at 1:100. |
UniProt Protein Function: | HSPA1L: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Not induced by heat shock. Expressed in spermatids. Belongs to the heat shock protein 70 family. |
UniProt Protein Details: | Protein type:Heat shock protein; Mitochondrial; Chaperone Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: signalosome; nucleoplasm; mitochondrial matrix; cytosol Molecular Function:protein binding; unfolded protein binding; ATP binding Biological Process: binding of sperm to zona pellucida; protein refolding; response to unfolded protein |
NCBI Summary: | This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | P34931 |
NCBI GenInfo Identifier: | 23831140 |
NCBI Gene ID: | 3305 |
NCBI Accession: | P34931.2 |
UniProt Secondary Accession: | P34931,O75634, Q2HXR3, Q8NE72, Q96QC9, Q9UQM1, A6NNB0 B0UXW8, |
UniProt Related Accession: | P34931 |
Molecular Weight: | 641 |
NCBI Full Name: | Heat shock 70 kDa protein 1-like |
NCBI Synonym Full Names: | heat shock 70kDa protein 1-like |
NCBI Official Symbol: | HSPA1LÂ Â |
NCBI Official Synonym Symbols: | HSP70T; hum70t; HSP70-1L; HSP70-HOMÂ Â |
NCBI Protein Information: | heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70kD protein-like 1; heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom |
UniProt Protein Name: | Heat shock 70 kDa protein 1-like |
UniProt Synonym Protein Names: | Heat shock 70 kDa protein 1-Hom; HSP70-Hom |
Protein Family: | Heat shock 70 kDa protein |
UniProt Gene Name: | HSPA1LÂ Â |
UniProt Entry Name: | HS71L_HUMAN |