Hspa1b Antibody (PACO27461)
- SKU:
- PACO27461
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Hspa1b Antibody (PACO27461)
The HSPA1B Antibody (PACO27461) is a crucial tool for researchers studying the HSPA1B protein, a member of the heat shock protein family involved in stress response and cell protection. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications.HSPA1B, also known as Hsp70-2, plays a vital role in cellular homeostasis by aiding in the folding and unfolding of proteins during stress conditions. Its function in protecting cells from damage and promoting cell survival highlights its importance in various biological processes. Research on HSPA1B is particularly relevant in the fields of molecular biology, cell biology, and cancer research.
By using the HSPA1B Antibody, researchers can effectively detect and analyze the expression levels of the HSPA1B protein in different cell types and experimental conditions. This antibody serves as a valuable tool for investigating the role of HSPA1B in cellular stress responses, disease development, and potential therapeutic interventions. Understanding the functions and regulation of HSPA1B is essential for advancing our knowledge of cellular biology and developing targeted treatments for diseases associated with protein misfolding and cellular stress.
| Antibody Name: | Hspa1b Antibody (PACO27461) |
| Antibody SKU: | PACO27461 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Heat shock 70 kDa protein 1B protein (2-642AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Hspa1b antibody at 5µg/ml Lane 1: A431 whole cell lysate Lane 2: A549 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: MCF-7 whole cell lysate Lane 5: K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 71 kDa Observed band size: 71 kDa . |
| Background: | In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. |
| Synonyms: | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 1) (HSP70.1), Hspa1b, Hcp70.1 Hsp70-1 Hsp70a1 Hspa1 |
| UniProt Protein Function: | HSP70: a critical chaperone protein that has a high affinity for unfolded polypeptide chains. It binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In cooperation with other chaperones, hsp70 stabilizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles. Mitochondrial HSP70 is crucial to the import process: mutant forms of HSP70 fail to import precursor proteins. Is anti-apoptotic in sympathetic neurones and mediates this effect primarily by suppressing c-Jun transcriptional signalling. Interacts with tau protein and mediates proper folding of tau. Can promote the degradation of tau protein. Triptolide, a potential therapeutic agent for progression/metastasis of pancreatic cancer, causes pancreatic cancer cell death by induction of apoptosis, an effect mediated by the inhibition of HSP70.Protein type: Chaperone; Heat shock protein; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 6p21.3Cellular Component: cell-cell adherens junction; centriole; cytoplasm; cytosol; focal adhesion; inclusion body; nucleoplasm; perinuclear region of cytoplasm; ubiquitin ligase complexMolecular Function: ATP binding; ATPase activity; ATPase activity, coupled; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; histone deacetylase binding; protein binding; receptor binding; ubiquitin protein ligase binding; unfolded protein bindingBiological Process: activation of NF-kappaB transcription factor; ATP metabolic process; negative regulation of protein ubiquitination; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein refolding; protein stabilization; regulation of mRNA stability; regulation of protein ubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17879 |
| NCBI GenInfo Identifier: | 167466173 |
| NCBI Gene ID: | 3304 |
| NCBI Accession: | |
| UniProt Secondary Accession: | P17879,P08107, P19790, Q5JQI4, Q5SP17, Q9UQL9, Q9UQM0 B4E3B6 |
| UniProt Related Accession: | P17879,P0DMV9 |
| Molecular Weight: | 70kDa |
| NCBI Full Name: | heat shock 70 kDa protein 1B |
| NCBI Synonym Full Names: | heat shock protein family A (Hsp70) member 1B |
| NCBI Official Symbol: | HSPA1BÂ Â |
| NCBI Official Synonym Symbols: | HSP70-2; HSP70.2; HSP70-1BÂ Â |
| NCBI Protein Information: | heat shock 70 kDa protein 1B |
| UniProt Protein Name: | Heat shock 70 kDa protein 1B |
| UniProt Synonym Protein Names: | Heat shock 70 kDa protein 2; HSP70-2 |
| Protein Family: | Heat shock 70 kDa protein |
| UniProt Gene Name: | HSPA1BÂ Â |
| UniProt Entry Name: | HS71B_HUMAN |
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