The HSPA1A Polyclonal Antibody (PACO07255) is a key tool for researchers studying the HSPA1A protein, a heat shock protein that plays a critical role in cellular stress response and protein folding. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications, enabling accurate detection and analysis of HSPA1A in various cell types.HSPA1A, also known as Hsp70, is involved in maintaining cellular protein homeostasis and promoting cell survival under stress conditions. Its function in chaperoning misfolded proteins and facilitating their refolding makes it a target of interest in research on diseases related to protein aggregation and cellular stress.
By studying HSPA1A, researchers can gain insights into the mechanisms underlying protein quality control and potentially identify novel therapeutic targets for conditions such as neurodegenerative diseases and cancer.Overall, the HSPA1A Polyclonal Antibody (PACO07255) is a valuable tool for investigating the role of HSPA1A in cellular physiology and disease pathogenesis, offering potential applications in a wide range of research areas, including molecular biology, cell biology, and biomedical sciences.
Antibody Name:
HSPA1A Antibody (PACO07255)
Antibody SKU:
PACO07255
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000-1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from HSP70 at AA range: 561-610
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of mouse-kidney mouse-heart mouse-brain mouse-lung Hela KB SH-SY5Y cells using HSP70 Polyclonal Antibody diluted at 1:2000. Secondary antibody was diluted at 1:20000.
Synonyms:
heat shock 70kDa protein 1A; heat shock 70kDa protein 1B
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
