The HSP90B1 Polyclonal Antibody (CAB6272) is a valuable tool for researchers studying heat shock protein 90 kDa beta member 1 (HSP90B1), a key chaperone protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.HSP90B1 plays a crucial role in maintaining protein homeostasis and cell survival, making it a critical player in cellular stress response pathways. By targeting HSP90B1 with this polyclonal antibody, researchers can study its expression and activity in various cell types, shedding light on its function in normal cellular processes and disease states.
With implications in cancer, neurodegenerative disorders, and other diseases characterized by protein misfolding, HSP90B1 is a promising target for therapeutic interventions. By utilizing the HSP90B1 Polyclonal Antibody (CAB6272), researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new strategies for treatment.
Product Name:
HSP90B1 Rabbit Polyclonal Antibody
SKU:
CAB6272
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 501-750 of human Grp94 (NP_003290.1).
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.
Purification Method:
Affinity purification
Gene ID:
7184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Grp94 Rabbit pAb (CAB6272) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
