The HSP90AB1 Polyclonal Antibody (CAB1087) is specifically designed for researchers studying the heat shock protein HSP90AB1, a chaperone protein essential for proper protein folding and cellular homeostasis. This antibody, produced through rabbit immunization, exhibits high reactivity with human samples and has been validated for use in Western blot applications.HSP90AB1 is a key player in cellular stress responses, aiding in the stabilization and activation of client proteins under conditions of environmental stress. Its role in protein quality control and cellular protection makes it an intriguing target for studies in various fields, including cancer research and neurodegenerative diseases.
By detecting and analyzing HSP90AB1 protein expression in different cell types, this antibody provides valuable insights into the molecular mechanisms underlying cellular stress responses and the potential therapeutic strategies targeting HSP90AB1 in disease contexts. Its sensitivity and specificity make it a reliable tool for researchers investigating the intricate workings of cellular stress pathways and protein folding mechanisms.
Product Name:
[KO Validated] Hsp90β Rabbit Polyclonal Antibody
SKU:
CAB1087
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human Hsp90β (NP_031381.2).
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
Purification Method:
Affinity purification
Gene ID:
3326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and Hsp90β knockout (KO) HeLa cells, using [KO Validated] Hsp90β Rabbit pAb (CAB1087) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
