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Anti-Hsp90 alpha Antibody (CAB12448)

SKU:
CAB12448
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-Hsp90 alpha Antibody CAB12448
  • Immunology Antibodies 1 Anti-Hsp90 alpha Antibody CAB12448
  • Immunology Antibodies 1 Anti-Hsp90 alpha Antibody CAB12448
  • Immunology Antibodies 1 Anti-Hsp90 alpha Antibody CAB12448
  • Immunology Antibodies 1 Anti-Hsp90 alpha Antibody CAB12448
€139 - €419
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Description

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Anti-Hsp90 alpha Antibody (CAB12448)

The HSP90AA1 Polyclonal Antibody (CAB12448) is specifically designed for research involving HSP90AA1, a heat shock protein that plays a crucial role in protein folding and cellular stress response. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.HSP90AA1 is an essential chaperone protein that assists in the folding and stabilization of a wide range of client proteins, including many involved in cell signaling and growth regulation. Its role in maintaining protein homeostasis makes it a key player in various cellular processes, including cancer development and progression.

By targeting HSP90AA1 with this antibody, researchers can effectively study the expression and activity of this important protein in different biological contexts.Given the significance of HSP90AA1 in cancer biology and other disease conditions, this polyclonal antibody is a valuable tool for researchers investigating the molecular mechanisms underlying disease pathogenesis and potential therapeutic interventions. Its high specificity and sensitivity make it an ideal choice for studies aiming to elucidate the role of HSP90AA1 in health and disease.

Antibody Name:Anti-Hsp90 alpha Antibody
Antibody SKU:CAB12448
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human Hsp90 alpha
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, 293T, MCF7, PC-12, mouse brain, rat brain
Immunogen:A synthetic peptide of human Hsp90 alpha
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3320
Uniprot:P07900
Cellular Location:Cell membrane, Cytoplasm, Melanosome
Calculated MW:84kDa/98kDa
Observed MW:101kDa
Synonyms:HSP90AA1, EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Background:The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11274138, PubMed:11276205, PubMed:15577939, PubMed:15937123, PubMed:27353360).
NCBI Summary:The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:P07900
NCBI GenInfo Identifier:92090606
NCBI Gene ID:3320
NCBI Accession:P07900.5
UniProt Secondary Accession:P07900,Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5, A8K500, B3KPJ9
UniProt Related Accession:P07900
Molecular Weight:98,161 Da
NCBI Full Name:Heat shock protein HSP 90-alpha
NCBI Synonym Full Names:heat shock protein 90 alpha family class A member 1
NCBI Official Symbol:HSP90AA1  
NCBI Official Synonym Symbols:EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p  
NCBI Protein Information:heat shock protein HSP 90-alpha
UniProt Protein Name:Heat shock protein HSP 90-alpha
UniProt Synonym Protein Names:Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
Protein Family:Heat shock protein
UniProt Gene Name:HSP90AA1  
Anti-Hsp90 alpha Antibody (CAB12448)Western blot analysis of extracts of various cell lines, using HSP90AA1 antibody (CAB12448) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-Hsp90 alpha Antibody (CAB12448)Immunohistochemistry of paraffin-embedded rat testis using HSP90AA1 antibody (CAB12448) at dilution of 1:200 (40x lens).
Anti-Hsp90 alpha Antibody (CAB12448)Immunohistochemistry of paraffin-embedded rat brain using HSP90AA1 antibody (CAB12448) at dilution of 1:200 (40x lens).
Anti-Hsp90 alpha Antibody (CAB12448)Immunohistochemistry of paraffin-embedded mouse testis using HSP90AA1 antibody (CAB12448) at dilution of 1:200 (40x lens).
Anti-Hsp90 alpha Antibody (CAB12448)Immunohistochemistry of paraffin-embedded mouse brain using HSP90AA1 antibody (CAB12448) at dilution of 1:200 (40x lens).

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