The HSP70 Polyclonal Antibody (CAB0284) is a valuable tool for researchers studying heat shock protein 70 (HSP70), a crucial protein involved in cellular stress response and protein folding. This rabbit-derived antibody is highly specific to HSP70 in human samples, making it reliable for Western blot applications.HSP70 is a chaperone protein that assists in the folding and unfolding of proteins, as well as in response to stressors like heat, infection, and inflammation. Its role in maintaining cell homeostasis and protecting against cellular damage highlights its importance in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By using the HSP70 Polyclonal Antibody, researchers can investigate the expression and function of HSP70 in different cell types and tissues, providing valuable insights into its role in cellular protection and disease pathogenesis. This antibody is a valuable tool for studies in molecular biology, cell biology, and therapeutic development aimed at targeting HSP70 for therapeutic applications.
Product Name:
HSP70 Rabbit Polyclonal Antibody
SKU:
CAB0284
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human HSP70 (NP_005336.3).
Sequence:
KITI TNDK GRLS KEEI ERMV QEAE KYKA EDEV QRER VSAK NALE SYAF NMKS AVED EGLK GKIS EADK KKVL DKCQ EVIS WLDA NTLA EKDE FEHK RKEL E
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Purification Method:
Affinity purification
Gene ID:
3303
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSP70 Rabbit pAb (CAB0284) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
