null

HSP27 Monoclonal Antibody [P2A5AT] (CPAB0281)

SKU:
CPAB0281
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P2A5AT
Applications:
WB
ELISA
IHC
€149
Frequently bought together:

Description

system_update_alt Datasheet

HSP27 Monoclonal Antibody [P2A5AT] (CPAB0281)

The HSP27 Antibody (CPAB0281) is a powerful tool for researchers interested in studying heat shock protein 27 (HSP27), a chaperone protein involved in cellular stress response and protection against apoptosis. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the HSP27 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential tool for investigations in molecular biology, cell biology, and cancer research.HSP27, also known as heat shock protein B1, is a key player in maintaining cellular homeostasis under stressful conditions, such as heat shock, oxidative stress, or exposure to toxins.

Its role in promoting cell survival and inhibiting programmed cell death has made it a target of interest in research on cancer, neurodegenerative diseases, and cardiovascular disorders. By studying the function and regulation of HSP27, researchers can gain valuable insights into the mechanisms of cellular stress response and potentially identify new therapeutic strategies for combating diseases associated with protein misfolding and proteotoxicity.

Product Name:HSP27 Antibody
Product Sku:CPAB0281
Size:5μg
Host Species:Mouse
Immunogen:Anti-human HSP27 mAb, is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HSP27 amino acids 1-25 purified from Ecoli.
Clone:P2A5AT.
Reactivity:Human
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:HSP27 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:HSP27 (also known as the Estrogen-Regulated 24K protein, and hsp 28) is a member of the mammalian small heat shock protein family. Hsp27 is expressed constitutively in many tissues and its expression is increased to high levels after various types of stress including elevated temperatures, toxic metals, drugs and oxidants. Also, Hsp27 is phosphorylated in vivo on three phosphorylation sites (Ser15, Ser78 and Ser82) by protein kinases including MAPKAP kinase 2 and the stress-activated protein kinase SAPK2 (p38).
Synonyms:HSPB1, CMT2F, HMN2B, HSP27, HSP28, HSP25, Heat shock protein beta-1, Heat shock 27 kDa protein, Stress-responsive protein 27, SRP27, HS.76067, DKFZp586P1322.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Related Products