The HSP105 Rabbit Monoclonal Antibody (CAB4687) is a cutting-edge research tool designed for the detection and analysis of HSP105, a heat shock protein involved in cellular stress response mechanisms. This highly reactive antibody, derived from rabbits, is validated for use in Western blot applications and is compatible with human samples. By binding specifically to the HSP105 protein, researchers can gain insights into its function in various cell types, making it an invaluable asset for studies in molecular biology and disease mechanisms.
HSP105 is a crucial player in maintaining cellular homeostasis during stress conditions, including heat shock, hypoxia, and oxidative stress. Its role in protecting cells from damage and promoting survival has made it a target of interest in research on cancer, neurodegenerative diseases, and other disorders involving cellular stress. By studying the activity of HSP105, scientists can uncover new therapeutic strategies for combating these conditions and enhancing cellular resilience.
Product Name:
HSP105/HSPH1 Rabbit Monoclonal Antibody
SKU:
CAB4687
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HSP105/HSPH1 (Q92598).
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
Purification Method:
Affinity purification
Gene ID:
10808
Clone Number:
ARC1092
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HSP105/HSPH1 Rabbit mAb (CAB4687) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
