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HSF4 Antibody (PACO09819)

SKU:
PACO09819
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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HSF4 Antibody (PACO09819)

The HSF4 Antibody (PACO09819) is a vital tool for researchers studying the Heat Shock Factor 4 (HSF4) protein, which plays a crucial role in the regulation of gene expression under heat stress conditions. This polyclonal antibody, produced using advanced technology, specifically targets HSF4 and is highly reactive with human samples. It has been validated for use in various applications, including Western blotting and immunohistochemistry, enabling accurate detection and analysis of HSF4 in different cell types.HSF4 is a key transcription factor that regulates the expression of heat shock proteins, which are essential for cellular stress responses and maintaining proteostasis.

Dysregulation of HSF4 has been implicated in various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic interventions. By using the HSF4 Antibody, researchers can gain valuable insights into the molecular mechanisms underlying HSF4-mediated gene regulation and its potential implications in disease pathogenesis.

Antibody Name:HSF4 Antibody (PACO09819)
Antibody SKU:PACO09819
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse
Immunogen:Human HSF4
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:heat shock transcription factor 4;HSF4;CTM ;
UniProt Protein Function:HSF4: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. Defects in HSF4 are the cause of cataract, zonular (CZ). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in HSF4 are the cause of cataract Marner type (CAM). A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds. Belongs to the HSF family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; Cell development/differentiation; DNA-binding

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: nucleoplasm

Molecular Function:transcription corepressor activity

Biological Process: regulation of transcription, DNA-dependent

Disease: Cataract 5, Multiple Types

NCBI Summary:Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULV5
NCBI GenInfo Identifier:296434534
NCBI Gene ID:3299
NCBI Accession:Q9ULV5.2
UniProt Secondary Accession:Q9ULV5,Q99472, Q9ULV6,
UniProt Related Accession:Q9ULV5
Molecular Weight:49,952 Da
NCBI Full Name:Heat shock factor protein 4
NCBI Synonym Full Names:heat shock transcription factor 4
NCBI Official Symbol:HSF4  
NCBI Official Synonym Symbols:CTM; CTRCT5  
NCBI Protein Information:heat shock factor protein 4
UniProt Protein Name:Heat shock factor protein 4
UniProt Synonym Protein Names:Heat shock transcription factor 4; HSTF 4
Protein Family:Heat shock factor protein
UniProt Gene Name:HSF4  
UniProt Entry Name:HSF4_HUMAN

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