The HSD3B2 Polyclonal Antibody (CAB1823) is a valuable tool for research involving the HSD3B2 protein, which is essential for steroid hormone biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the HSD3B2 protein, enabling precise detection and analysis in a variety of cell types.HSD3B2 is a key enzyme involved in the production of steroid hormones, including cortisol and aldosterone, which play crucial roles in various physiological processes. Dysregulation of HSD3B2 activity has been implicated in several diseases, such as adrenal disorders and hormone-related cancers.
By studying the expression and function of HSD3B2 using this antibody, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the HSD3B2 Polyclonal Antibody (CAB1823) is an essential tool for investigating the role of HSD3B2 in steroid hormone biosynthesis and its implications for health and disease. Its high specificity and sensitivity make it suitable for a wide range of research applications, from basic biology to clinical studies.
Product Name:
HSD3B2 Rabbit Polyclonal Antibody
SKU:
CAB1823
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human HSD3B2 (NP_000189.1).
The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with HSD3B2, using HSD3B2 Rabbit pAb (CAB1823) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.5s.
