HSD17B8 Rabbit Polyclonal Antibody (CAB12947)
- SKU:
- CAB12947
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | HSD17B8 Rabbit Polyclonal Antibody |
SKU: | CAB12947 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human HSD17B8 (NP_055049.1). |
Sequence: | MASQ LQNR LRSA LALV TGAG SGIG RAVS VRLA GEGA TVAA CDLD RAAA QETV RLLG GPGS KEGP PRGN HAAF QADV SEAR AARC LLEQ VQAC FSRP PSVV VSCA GITQ DEFL LHMS EDDW DKVI AVNL KGTF LVTQ AAAQ ALVS NGCR GSII NISS IVGK VGNV GQTN YAAS KAGV IGLT QTAA RELG RHGI RCNS VLPG FIAT PMTQ KVPQ KVVD KITE MIPM GHLG DPED VADV VAFL ASED SGYI TGTS VEVT GGLF M |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9; HSD17B8 |
Positive Sample: | HepG2,BxPC-3,U-87MG,HeLa,Mouse liver,Mouse pancreas,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 27kDa |
Observed MW: | 27kDa |
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 7923 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |