The HSD17B3 Polyclonal Antibody (CAB7687) is a valuable tool for researchers studying HSD17B3, an enzyme involved in steroid hormone biosynthesis. This antibody, generated from rabbit immunizations, specifically targets HSD17B3 in human samples and is validated for use in Western blot assays.HSD17B3 is a key enzyme in the conversion of estrone to estradiol, a process involved in hormone production and regulation. Dysregulation of HSD17B3 activity has been implicated in various hormone-related disorders, including hormone-dependent cancers and metabolic diseases.
By targeting HSD17B3 with this antibody, researchers can investigate its expression and function in different cell types, providing insights into its role in hormone metabolism and related conditions.By using the HSD17B3 Polyclonal Antibody (CAB7687), researchers can further explore the mechanisms underlying hormone biosynthesis and related diseases, ultimately contributing to the development of targeted therapies and interventions for hormone-related disorders.
Product Name:
HSD17B3 Rabbit Polyclonal Antibody
SKU:
CAB7687
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1).
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
Purification Method:
Affinity purification
Gene ID:
3293
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with HSD17B3 using HSD17B3 Rabbit pAb (CAB7687) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
