The HSD17B2 Polyclonal Antibody (CAB1983) is a valuable tool for researchers studying the HSD17B2 protein, which is involved in steroid metabolism and has been implicated in various diseases, including hormone-dependent cancers. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the HSD17B2 protein, this antibody allows for the detection and analysis of this important enzyme in a variety of cell types.HSD17B2, also known as 17-beta-hydroxysteroid dehydrogenase type 2, plays a crucial role in the biosynthesis and inactivation of steroid hormones, making it a potential target for therapeutic interventions in hormone-related conditions.
The dysregulation of HSD17B2 has been linked to hormone-sensitive cancers, such as breast and prostate cancer, highlighting its importance in cancer research and drug development. By understanding the function and regulation of HSD17B2, researchers can gain insight into the mechanisms underlying these diseases and potentially identify novel treatment strategies.
Product Name:
HSD17B2 Rabbit Polyclonal Antibody
SKU:
CAB1983
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human HSD17B2 (NP_002144.1).
Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane.
Purification Method:
Affinity purification
Gene ID:
3294
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HSD17B2 antibody (CAB1983) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.1s.
