The HSD17B14 Polyclonal Antibody (PAC016493) is a valuable tool for research involving HSD17B14, an enzyme involved in steroid metabolism and potentially linked to cancer progression. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the HSD17B14 protein, this antibody allows for the detection and analysis of HSD17B14 in various cell types, making it ideal for studies in cancer research and steroid hormone metabolism.
HSD17B14 has been implicated in the development and progression of various cancers, making it a promising target for therapeutic intervention. By understanding the role of HSD17B14 in cancer biology, researchers can potentially identify new treatment strategies and biomarkers for early detection. The HSD17B14 Polyclonal Antibody offers a reliable tool for studying the function and regulation of this enzyme in cancer and other related diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16493(HSD17B14 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: PACO16493(HSD17B14 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16493(HSD17B14 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acid, , prostaglandins, and xenobiotics.
Synonyms:
hydroxysteroid (17-beta) dehydrogenase 14
UniProt Protein Function:
HSD17B14: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: EC 1.1.1.-; OxidoreductaseChromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytosolMolecular Function: estradiol 17-beta-dehydrogenase activity; identical protein binding; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activityBiological Process: estrogen biosynthetic process; steroid catabolic process
UniProt Protein Details:
NCBI Summary:
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1
