HSD17B11 Antibody (PACO39126)
- SKU:
- PACO39126
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
HSD17B11 Antibody (PACO39126)
The HSD17B11 Polyclonal Antibody (PAC039126) is a valuable tool for research focused on HSD17B11, an enzyme involved in the biosynthesis of steroids and fatty acids. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the HSD17B11 protein, researchers can accurately detect and analyze its presence in a variety of cell types, making it ideal for studies in biochemistry and endocrine research.
HSD17B11 plays a crucial role in steroid hormone metabolism and lipid biosynthesis, making it a target of interest in studies related to hormone-related disorders, metabolic diseases, and cancer. Understanding the function and regulation of HSD17B11 is essential for developing targeted therapies that can modulate its activity in disease states, potentially leading to novel treatment strategies for a variety of conditions.
| Antibody Name: | HSD17B11 Antibody (PACO39126) |
| Antibody SKU: | PACO39126 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Estradiol 17-beta-dehydrogenase 11 protein (20-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: HSD17B11 antibody at 10µg/ml + Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 33 kDa. Observed band size: 33 kDa. |
| Background: | Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. |
| Synonyms: | Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2), HSD17B11, DHRS8 PAN1B SDR16C2 |
| UniProt Protein Function: | HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.1.1.62Chromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particleMolecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activityBiological Process: androgen catabolic process; estrogen biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q8NBQ5 |
| NCBI GenInfo Identifier: | 296439374 |
| NCBI Gene ID: | 51170 |
| NCBI Accession: | Q8NBQ5.3 |
| UniProt Secondary Accession: | Q8NBQ5,Q96HF6, Q9UKU4 |
| UniProt Related Accession: | Q8NBQ5 |
| Molecular Weight: | 32,936 Da |
| NCBI Full Name: | Estradiol 17-beta-dehydrogenase 11 |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 11 |
| NCBI Official Symbol: | HSD17B11Â Â |
| NCBI Official Synonym Symbols: | DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXIÂ Â |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 11 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 11 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Short chain dehydrogenase/reductase family 16C member 2 |
| Protein Family: | Estradiol 17 beta-dehydrogenase |
| UniProt Gene Name: | HSD17B11Â Â |
| UniProt Entry Name: | DHB11_HUMAN |
Related Products
HSD17B11 Antibody (PACO09807)
€459
HSD17B11 Antibody (PACO00344)
€269
