The HSD17B11 Polyclonal Antibody (PACO00344) is a valuable tool for researchers studying the HSD17B11 protein, which plays a crucial role in steroid hormone metabolism. This antibody, raised in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.HSD17B11 is a key enzyme involved in the conversion of estrone to estradiol, a process that is important for proper hormonal balance in the body. Dysregulation of HSD17B11 has been implicated in various hormone-related disorders, including breast and prostate cancer. By targeting the HSD17B11 protein, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.
The HSD17B11 Polyclonal Antibody is a reliable tool for detecting and analyzing HSD17B11 expression in a variety of cell types, making it an indispensable resource for studies in endocrinology, cancer research, and hormone-related disorders. Its high specificity and sensitivity make it a valuable asset for researchers seeking to unravel the complexities of steroid hormone metabolism and its implications for human health.
Antibody Name:
HSD17B11 Antibody
Antibody SKU:
PACO00344
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human 17Beta-HSD11.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.1.1.62Chromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particleMolecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activityBiological Process: androgen catabolic process; estrogen biosynthetic process
UniProt Protein Details:
NCBI Summary:
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
