The HSD17B10 Polyclonal Antibody (CAB5448) is a valuable tool for researchers studying the HSD17B10 protein, which is involved in various metabolic pathways and has been implicated in diseases such as Alzheimer's and X-linked mental retardation. This antibody is produced in rabbits and has been validated for use in Western blot applications, allowing for the detection and analysis of HSD17B10 in different cell types.HSD17B10, also known as 17-beta-hydroxysteroid dehydrogenase type 10, plays a critical role in fatty acid metabolism and the breakdown of isoleucine, among other functions.
Dysregulation of HSD17B10 has been linked to metabolic disorders and neurodegenerative diseases, making it an important target for research aimed at understanding these conditions and developing potential therapies.The HSD17B10 Polyclonal Antibody is highly specific and sensitive, providing researchers with a reliable tool for investigating the function and regulation of the HSD17B10 protein. Its applications in immunology, metabolism, and neurology make it a valuable asset for studies seeking to elucidate the role of HSD17B10 in health and disease.
Product Name:
ERAB/HSD17B10 Rabbit Polyclonal Antibody
SKU:
CAB5448
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human ERAB/ERAB/HSD17B10 (NP_004484.1).
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Purification Method:
Affinity purification
Gene ID:
3028
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERAB/HSD17B10 Rabbit pAb (CAB5448) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
