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HSD17B1 Rabbit Polyclonal Antibody (CAB10839)

SKU:
CAB10839
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
  • Metabolism Antibodies 1 Anti-HSD17B1 Antibody CAB10839
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:HSD17B1 Rabbit Polyclonal Antibody
SKU:CAB10839
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-328 of human HSD17B1 (NP_000404.2).
Sequence:MART VVLI TGCS SGIG LHLA VRLA SDPS QSFK VYAT LRDL KTQG RLWE AARA LACP PGSL ETLQ LDVR DSKS VAAA RERV TEGR VDVL VCNA GLGL LGPL EALG EDAV ASVL DVNV VGTV RMLQ AFLP DMKR RGSG RVLV TGSV GGLM GLPF NDVY CASK FALE GLCE SLAV LLLP FGVH LSLI ECGP VHTA FMEK VLGS PEEV LDRT DIHT FHRF YQYL AHSK QVFR EAAQ NPEE VAEV FLTA LRAP KPTL RYFT TERF LPLL RMRL DDPS GSNY VTAM HREV FGDV PAKA EAGA EAGG GAGP GAED EAGR GAVG DPEL GDPP AAPQ
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:E2DH; HSD17; EDHB17; EDH17B2; SDR28C1; 17-beta-HSD; 20-alpha-HSD; HSD17B1
Positive Sample:U-87MG,Rat ovary
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:35kDa
Observed MW:35kDa

This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:3292
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using HSD17B1 Rabbit pAb (CAB10839) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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