HSD11B2 Rabbit Polyclonal Antibody (CAB8077)
- SKU:
- CAB8077
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | HSD11B2 Rabbit Polyclonal Antibody |
SKU: | CAB8077 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 266-405 of human HSD11B2 (NP_000187.3). |
Sequence: | KTES VRNV GQWE KRKQ LLLA NLPQ ELLQ AYGK DYIE HLHG QFLH SLRL AMSD LTPV VDAI TDAL LAAR PRRR YYPG QGLG LMYF IHYY LPEG LRRR FLQA FFIS HCLP RALQ PGQP GTTP PQDA AQDP NLSP GPSP AVAR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 |
Synonyms: | AME; AME1; HSD2; HSD11K; SDR9C3; HSD11B2 |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Microsome. |
Calculated MW: | 44kDa |
Observed MW: | 44kDa |
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Purification Method: | Affinity purification |
Gene ID: | 3291 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |