The HSD11B1L Polyclonal Antibody (PAC037334) is a valuable tool for researchers studying the HSD11B1L protein, which plays a crucial role in regulating cortisol levels and has been implicated in various metabolic and inflammatory disorders. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.HSD11B1L, also known as 11-beta-hydroxysteroid dehydrogenase type 1-like, is involved in converting inactive cortisone to active cortisol, a hormone that influences metabolism, inflammation, and stress response.
Dysregulation of HSD11B1L has been linked to conditions such as obesity, diabetes, and cardiovascular disease, making it a promising target for therapeutic interventions.By binding specifically to the HSD11B1L protein, this antibody allows for the accurate detection and quantification of HSD11B1L levels in various biological samples, facilitating research in endocrinology, metabolism, and related fields. Investigating the role of HSD11B1L may lead to a better understanding of these disorders and the development of targeted treatments to address them.
Antibody Name:
HSD11B1L Antibody (PACO37334)
Antibody SKU:
PACO37334
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Hydroxysteroid 11-beta-dehydrogenase 1-like protein (17-87AA)
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO37334 at dilution of 1:100.
Synonyms:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) (Short chain dehydrogenase/reductase family 26C member 2) (Short-chain dehydrogenase/reductase 10), HSD11B1L, HSD3 SCDR10 SDR26C2
UniProt Protein Function:
HSD11B1L: a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]Protein type: Secreted, signal peptide; Oxidoreductase; EC 1.1.1.-; SecretedChromosomal Location of Human Ortholog: 19p13.3
UniProt Protein Details:
NCBI Summary:
This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1-like, mRNA
NCBI Synonym Full Names:
hydroxysteroid 11-beta dehydrogenase 1 like
NCBI Official Symbol:
HSD11B1LÂ Â
NCBI Official Synonym Symbols:
HSD3; 11-DH3; SCDR10; SCDR10B; SDR26C2; 11-beta-HSD3Â Â
NCBI Protein Information:
hydroxysteroid 11-beta-dehydrogenase 1-like protein
UniProt Protein Name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein
UniProt Synonym Protein Names:
11-beta-hydroxysteroid dehydrogenase type 3; 11-DH3; 11-beta-HSD3; Short chain dehydrogenase/reductase family 26C member 2; Short-chain dehydrogenase/reductase 10
Protein Family:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein
