HSD11B1 Rabbit Polyclonal Antibody (CAB1619)
- SKU:
- CAB1619
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | HSD11B1 Rabbit Polyclonal Antibody |
SKU: | CAB1619 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-292 of human HSD11B1 (NP_005516.1). |
Sequence: | EEFR PEML QGKK VIVT GASK GIGR EMAY HLAK MGAH VVVT ARSK ETLQ KVVS HCLE LGAA SAHY IAGT MEDM TFAE QFVA QAGK LMGG LDML ILNH ITNT SLNL FHDD IHHV RKSM EVNF LSYV VLTV AALP MLKQ SNGS IVVV SSLA GKVA YPMV AAYS ASKF ALDG FFSS IRKE YSVS RVNV SITL CVLG LIDT ETAM KAVS GIVH MQAA PKEE CALE IIKG GALR QEEV YYDS SLWT TLLI RNPC RKIL EFLY STSY NMDR FINK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1; HSD11B1 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Single-pass type II membrane protein. |
Calculated MW: | 32kDa |
Observed MW: | 32kDa |
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Purification Method: | Affinity purification |
Gene ID: | 3290 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |