Hsc70-interacting protein (HIP) Rabbit Monoclonal Antibody (CAB9567)
The Hsc70 Interacting Protein (HIP) Rabbit Monoclonal Antibody (CAB9567) is a valuable tool for researchers studying protein interactions involved in cellular processes. This antibody, produced in rabbits, specifically targets the HIP protein, which plays a crucial role in regulating the activity of Hsc70, a molecular chaperone involved in protein folding and quality control.The HIP antibody is highly reactive with human samples and has been validated for use in Western blot applications, making it suitable for protein interaction studies in various cell types. By detecting and analyzing the HIP protein, researchers can gain insights into how it influences the function of Hsc70 and its impact on cellular pathways.
Given the importance of chaperone proteins like Hsc70 in maintaining protein homeostasis and cellular function, understanding the role of HIP in these processes is essential for unraveling the mechanisms underlying diseases such as neurodegenerative disorders, cancer, and protein aggregation diseases. The HIP antibody offers a reliable tool for investigating these complex protein interactions and their implications for human health.
Product Name:
Hsc70-interacting protein (HIP) Rabbit Monoclonal Antibody
SKU:
CAB9567
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 270-369 of human Hsc70-interacting protein (HIP) (P50502).
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6767
Clone Number:
ARC1639
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Hsc70-interacting protein (HIP) Rabbit mAb (CAB9567) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
