The HSBP1 Polyclonal Antibody (PACO25508) is a valuable tool for researchers studying HSBP1, a protein involved in various cellular processes and functions. This antibody, raised in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to the HSBP1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and cell biology research.HSBP1, also known as heat shock factor binding protein 1, plays a crucial role in regulating cellular responses to stress, such as heat shock and DNA damage. Its involvement in protein folding and intracellular signaling pathways highlights its importance in maintaining cellular homeostasis.
Research into HSBP1 can provide insights into mechanisms of cellular stress response and potential therapeutic targets for diseases related to protein misfolding and cellular damage.In conclusion, the HSBP1 Polyclonal Antibody (PACO25508) offers researchers a reliable tool for investigating the functions and mechanisms of HSBP1 in various cellular contexts. Its specificity and sensitivity make it a valuable asset for studies aiming to elucidate the role of HSBP1 in cellular stress responses and disease pathways.
Antibody Name:
HSBP1 Antibody (PACO25508)
Antibody SKU:
PACO25508
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Heat shock factor-binding protein 1 protein (1-75AA)
Immunohistochemistry of paraffin-embedded human lung tissue using PACO25508 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO25508 at dilution of 1:100.
Background:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
HSBP1: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Belongs to the HSBP1 family.Chromosomal Location of Human Ortholog: 16q23.3Cellular Component: nucleoplasm; cytoskeleton; nucleusMolecular Function: transcription corepressor activityBiological Process: muscle contraction; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
