The HS3ST1 Polyclonal Antibody (PAC027453) is a powerful tool for research involving HS3ST1, a key enzyme involved in heparan sulfate biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blotting. By binding specifically to the HS3ST1 protein, this antibody enables the detection and analysis of HS3ST1 in various cell types, making it an ideal choice for studies in glycobiology and cancer research.HS3ST1 plays a crucial role in the modification of heparan sulfate proteoglycans, which are involved in a wide range of biological processes, including cell signaling, cell adhesion, and tissue development.
Dysregulation of HS3ST1 expression has been implicated in various diseases, such as cancer and certain genetic disorders. Therefore, investigating the function and regulation of HS3ST1 is essential for gaining insights into disease mechanisms and developing potential therapeutic strategies.The HS3ST1 Polyclonal Antibody offers researchers a reliable tool for studying the role of HS3ST1 in health and disease, providing valuable information that can contribute to advancements in the fields of molecular biology and medicine.
Antibody Name:
HS3ST1 Antibody (PACO27453)
Antibody SKU:
PACO27453
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Heparan sulfate glucosamine 3-O-sulfotransferase 1 protein (21-307AA)
Immunohistochemistry of paraffin-embedded human heart tissue using PACO27453 at dilution of 1:100.
Background:
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
HS3ST1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Belongs to the sulfotransferase 1 family.Protein type: EC 2.8.2.23; Transferase; Glycan Metabolism - heparan sulfate biosynthesisChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi lumen; integral to membraneMolecular Function: sulfotransferase activity; heparin-glucosamine 3-O-sulfotransferase activityBiological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis
UniProt Protein Details:
NCBI Summary:
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
