The HS3ST1 Polyclonal Antibody (PACO09802) is a valuable tool for researchers studying HS3ST1, an enzyme involved in heparan sulfate biosynthesis. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.HS3ST1 plays a crucial role in modifying heparan sulfate chains, which are essential components of the extracellular matrix and cell surface. Dysregulation of HS3ST1 expression has been linked to various diseases, including cancer and neurodegenerative disorders.
Therefore, understanding the function of HS3ST1 is vital for developing targeted therapies for these conditions.By utilizing the HS3ST1 Polyclonal Antibody, researchers can accurately detect and analyze HS3ST1 levels in different cell types, facilitating investigations into the enzyme's role in disease pathogenesis. This antibody is a valuable tool for advancing our understanding of heparan sulfate biosynthesis and its implications in human health.
HS3ST1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Belongs to the sulfotransferase 1 family.Protein type: EC 2.8.2.23; Transferase; Glycan Metabolism - heparan sulfate biosynthesisChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi lumen; integral to membraneMolecular Function: sulfotransferase activity; heparin-glucosamine 3-O-sulfotransferase activityBiological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis
UniProt Protein Details:
NCBI Summary:
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
