The HS2ST1 Polyclonal Antibody (CAB13837) is a versatile tool for researchers investigating HS2ST1, an enzyme involved in the biosynthesis of heparan sulfate. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the HS2ST1 protein, this antibody facilitates the detection and analysis of HS2ST1 in various cell types, making it an invaluable resource for studies in glycobiology and cancer research.HS2ST1 plays a crucial role in modifying heparan sulfate chains, thereby impacting various biological processes such as cell adhesion, signaling, and development.
Dysregulation of HS2ST1 has been linked to cancer progression, angiogenesis, and metastasis, highlighting its potential as a therapeutic target. Research focused on understanding the function of HS2ST1 is essential for unraveling the complex mechanisms underlying these disease processes and identifying novel treatment strategies.Overall, the HS2ST1 Polyclonal Antibody offers researchers a reliable tool for investigating the role of HS2ST1 in health and disease, paving the way for advancements in precision medicine and targeted therapies.
Product Name:
HS2ST1 Rabbit Polyclonal Antibody
SKU:
CAB13837
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human HS2ST1 (NP_001127964.1).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
42kDa
Observed MW:
42kDa
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HS2ST1 Rabbit pAb (CAB13837) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
