The HRK Polyclonal Antibody (PACO19792) is a valuable tool for researchers studying the HRK protein, a key regulator of apoptosis in cells. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding specifically to the HRK protein, this antibody allows for easy detection and analysis in a variety of cell types, making it ideal for studies in cell biology, cancer research, and apoptosis regulation.HRK, also known as harakiri, is a pro-apoptotic protein that plays a crucial role in programmed cell death by promoting mitochondrial membrane permeabilization.
Dysregulation of HRK has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Research into the function and regulation of HRK is vital for understanding the mechanisms of cell death and developing targeted therapies for diseases associated with apoptosis dysregulation.Overall, the HRK Polyclonal Antibody is a valuable tool for researchers investigating the role of HRK in cell death pathways and its potential as a therapeutic target in various diseases. Its high specificity and reactivity make it a reliable choice for studying the molecular mechanisms underlying apoptosis.
Antibody Name:
HRK Antibody (PACO19792)
Antibody SKU:
PACO19792
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human HRK
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19792(HRK Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19792(HRK Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants.
Synonyms:
harakiri, BCL2 interacting protein (contains only BH3 domain)
UniProt Protein Function:
HRK: Promotes apoptosis.Protein type: Membrane protein, integral; ApoptosisChromosomal Location of Human Ortholog: 12q24.22Cellular Component: mitochondrion; integral to membraneMolecular Function: protein bindingBiological Process: apoptosis; positive regulation of apoptosis; positive regulation of protein homooligomerization
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
activator of apoptosis harakiri; death protein 5; BCL2-interacting protein; activator of apoptosis Hrk; neuronal death protein DP5; BH3-interacting domain-containing protein 3; harakiri, BCL2 interacting protein (contains only BH3 domain)
UniProt Protein Name:
Activator of apoptosis harakiri
UniProt Synonym Protein Names:
BH3-interacting domain-containing protein 3; Neuronal death protein DP5
