The HRH3 Polyclonal Antibody (CAB16497) is a valuable tool for researchers studying the histamine H3 receptor, a G protein-coupled receptor that plays a key role in neurotransmission and immune response modulation. This antibody is produced in rabbits and has been validated for use in Western blot applications, allowing for the detection and analysis of HRH3 protein in human samples. The histamine H3 receptor has been implicated in various physiological processes, including cognition, memory, and inflammation. Its dysregulation has been linked to neurological disorders, such as Alzheimer's disease and schizophrenia, making it a potential therapeutic target for drug development.
By using the HRH3 Polyclonal Antibody, researchers can investigate the expression and function of HRH3 in different cell types, advancing our understanding of its role in health and disease. Overall, the HRH3 Polyclonal Antibody is an essential tool for researchers interested in studying the histamine H3 receptor and its implications in neurobiology and immunology. Its high reactivity and specificity make it well-suited for a variety of applications, supporting cutting-edge research in pharmacology and neuroscience.
Product Name:
HRH3 Rabbit Polyclonal Antibody
SKU:
CAB16497
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HRH3 (NP_009163.2).
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.
Purification Method:
Affinity purification
Gene ID:
11255
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat brain, using HRH3 antibody (CAB16497) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
