The HRG Polyclonal Antibody (CAB8431) is specifically designed for research involving the HRG protein, a key player in the regulation of growth and differentiation in various cell types. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for reliable use in Western blot applications. By binding to the HRG protein, this antibody enables the detection and analysis of HRG expression in different cell types, making it an essential tool for studies in molecular biology, cell signaling, and cancer research.
HRG, also known as histidine-rich glycoprotein, is involved in a wide range of physiological processes including angiogenesis, wound healing, and immune response modulation. Its diverse roles in cellular function make it a valuable target for investigating various diseases such as cancer, cardiovascular disorders, and inflammatory conditions. Understanding the function of HRG is crucial for developing novel therapeutic strategies that target this protein to treat or prevent these diseases effectively.
Product Name:
HRG Rabbit Polyclonal Antibody
SKU:
CAB8431
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human HRG (NP_000403.1).
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
Purification Method:
Affinity purification
Gene ID:
3273
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse pancreas, using HRG antibody (CAB8431) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
